![]() ![]() Because the fundamental etiology of depression is not clear, recreating a perfect animal depression model that captures every and all aspects of the disease is nearly impossible. Despite the large volume of studies devoted to depression research, our understanding of depression is still limited to this day, partially because depression is a heterogeneous disease that varies in symptomologies and underlying pathophysiology. In addition to causing personal distress, depression also plays a large role in suicide attempts, with one-half of all suicide attempts linked to depression and nearly 20% lifetime suicide risk if left untreated. Symptoms of depression include heightened negative affect (negative moods, e.g., feeling nervous, scared, and guilt, etc.) and diminished positive affect (positive moods, e.g., feeling less motivated, loss of pleasure, harder to concentrate, etc.). Major Depressive Disorder (MDD) is a leading cause of disability, with around 300 million people afflicted with depression worldwide, according to the World Health Organization. Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Visualization, Writing – original draft, Writing – review & editingĪffiliation: Department of Psychology, University of Minnesota, Minneapolis, Minnesota, United States of America ![]()
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